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Structure of 189283-51-0
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3,4-Difluoro-2-hydroxybenzoic acid features a trifunctional aromatic core with fluorine substituents at the 3 and 4 positions, a hydroxyl group at C2, and a carboxylic acid moiety. This arrangement imparts enhanced electron-withdrawing character, improved metabolic stability, and favorable solubility for use in medicinal chemistry scaffolds and bioactive molecule synthesis.
3,4-Difluoro-2-hydroxybenzoic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation into bioactive scaffolds via standard esterification, amidation, and coupling reactions. The ortho-hydroxyl group facilitates chelation and enhances solubility, while the difluorinated aromatic ring improves metabolic stability and modulates electronic properties. Bench-stable and readily purified by recrystallization, it functions effectively in multi-step syntheses requiring high functional group tolerance.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: