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Structure of 1893408-14-4
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Tert-butyl (R)-3,3-difluoro-4-hydroxypiperidine-1-carboxylate features a stereochemically defined piperidine core with two fluorine atoms at the 3-position and a hydroxyl group at C4. This bench-stable, moisture-tolerant building block integrates readily into bioactive molecule synthesis, offering enhanced metabolic stability and controlled polarity for medicinal chemistry applications.
Tert-butyl (R)-3,3-difluoro-4-hydroxypiperidine-1-carboxylate serves as a stereochemically defined building block for fluorinated piperidine scaffolds. The difluoro substitution at C3 enhances metabolic stability and modulates basicity, while the pendant hydroxyl group enables direct functionalization or derivatization. This robust intermediate exhibits excellent bench stability, facilitates purification via standard chromatography, and functions effectively in amide coupling, reductive amination, and nucleophilic substitution reactions, making it well-suited for medicinal chemistry campaigns targeting CNS and oncology therapeutics.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: