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Structure of 1246999-33-6
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Tos-PEG4-NH-Boc features a tert-butyl carbamate-protected amine linked via a four-unit polyethylene glycol spacer to a tosylated terminus. This bifunctional reagent enables site-specific conjugation in aqueous environments, combining the stability of the Boc group with the solubility and biocompatibility of PEG. Ideal for peptide derivatization and bioconjugation workflows requiring orthogonal protection and controlled release.
Tos-PEG4-NH-Boc serves as a versatile bifunctional building block for peptide and oligonucleotide conjugation, enabling efficient N-terminal capping and site-specific attachment. The tosyl (Tos) group provides a robust leaving group for nucleophilic substitution, while the PEG4 spacer offers enhanced solubility and reduced aggregation. The Boc-protected amine facilitates subsequent deprotection and functionalization under standard acidic conditions. This structure enables clean, high-yielding coupling reactions with minimal side-product formation, making it ideal for modular synthesis of bioconjugates and peptidomimetics.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P264-P280-P302+P352-P362+P364
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Lot numbers can be found on the outside label of a product: