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Structure of 19346-43-1
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2-Fluoro-4-methyl-3-nitropyridine features a trifunctional pyridine core with electron-withdrawing nitro and fluoro groups paired with an electron-donating methyl substituent. This electronic asymmetry enables selective coupling in cross-coupling reactions, particularly under palladium catalysis. The molecule exhibits enhanced stability and solubility in polar aprotic solvents, facilitating use in synthetic sequences requiring precise regiocontrol.
2-Fluoro-4-methyl-3-nitropyridine serves as a versatile building block in medicinal chemistry, enabling efficient access to functionalized pyridine scaffolds. Its orthogonal reactivity—combining electrophilic fluorination with nucleophilic displacement at C2—facilitates late-stage diversification. The nitro group supports subsequent reduction and coupling transformations, while the methyl group provides a handle for further modification. Bench-stable and compatible with standard synthetic workflows, it functions effectively in cross-coupling, amidation, and heterocycle formation protocols.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: