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Structure of 19346-45-3
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2-Fluoro-6-methyl-3-nitropyridine features a trifunctional pyridine core with electron-withdrawing nitro and fluoro groups paired with an electron-donating methyl substituent. This electronic asymmetry enables selective functionalization in cross-coupling reactions, particularly in the development of fluorinated heterocyclic scaffolds for medicinal chemistry applications.
2-Fluoro-6-methyl-3-nitropyridine serves as a versatile building block in medicinal chemistry, enabling regioselective functionalization at the pyridine ring due to orthogonal electronic activation by the nitro and fluorine substituents. Its bench-stable nature and compatibility with palladium-catalyzed cross-coupling reactions facilitate efficient access to substituted heterocycles. The methyl group provides a handle for further derivatization, while the nitro function supports reduction to an amine or conversion into other nitrogen-containing scaffolds common in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: