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CS-W001157 4
Total: USD 88.00

2-Fluoro-4-methyl-5-nitropyridine

  • CAS No. 19346-47-5

  • Cat. No. CS-W019716
  • Purity≥98%
  • MDL No.MFCD03095070

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-4-methyl-5-nitropyridine|CS-W019716

Structure of 19346-47-5

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General Information

  • CAS No. 19346-47-5
  • Cat. No. CS-W019716
  • Purity ≥98%
  • MDL No. MFCD03095070
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅FN₂O₂
  • Molecular Weight 156.11
  • Synonym(s) None
  • SMILES O=[N+](C1=CN=C(F)C=C1C)[O-]

Description

2-Fluoro-4-methyl-5-nitropyridine is a bench-stable, electron-deficient heterocycle featuring a fluorine atom at the 2-position and a nitro group at the 5-position. This combination enhances electrophilicity at the pyridine ring, enabling efficient coupling reactions in cross-coupling and nucleophilic substitution processes. The methyl substituent provides steric and electronic modulation, improving solubility and reactivity control in synthetic transformations.

Application

2-Fluoro-4-methyl-5-nitropyridine serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The fluorine and nitro groups provide orthogonal reactivity for selective transformations, while the methyl group enhances metabolic stability. Its bench-stable nature and compatibility with diverse reaction conditions facilitate rapid access to substituted pyridine scaffolds relevant to API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   56.03
  • LogP   1.43732
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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