3-(Difluoromethyl)-1-methyl-1H-pyrazol-4-amine hydrochloride

Name: 3-(Difluoromethyl)-1-methyl-1H-pyrazol-4-amine hydrochloride
Brand: ChemScene
Availability: InStock
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CAS No. 1946817-21-5
Cat. No. CS-0343126
Purity≥98%
MDL No.None

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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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3-(Difluoromethyl)-1-methyl-1H-pyrazol-4-amine hydrochloride|CS-0343126

Structure of 1946817-21-5

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Description

This difluoromethyl-substituted pyrazole integrates a sterically accessible methylated amine handle, enabling direct functionalization in late-stage diversification. The hydrochloride salt enhances solubility and stability under standard bench conditions, facilitating use in synthetic organic chemistry workflows requiring polar, electron-deficient heterocyclic scaffolds.

Application

3-(Difluoromethyl)-1-methyl-1H-pyrazol-4-amine hydrochloride serves as a versatile building block in medicinal chemistry, enabling direct incorporation of a difluoromethyl group adjacent to a pyrazole nitrogen. The compound exhibits enhanced metabolic stability and favorable lipophilicity, facilitating its use in the synthesis of bioactive heterocycles. Its amine functionality supports straightforward derivatization via coupling reactions, while the hydrochloride salt ensures improved crystallinity and shelf stability for routine bench handling.

General Information

CAS No. 1946817-21-5
Cat. No. CS-0343126
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₈ClF₂N₃
Molecular Weight 183.59
Synonym(s) None
SMILES FC(C1=NN(C)C=C1N)F.Cl

Computational Chemistry Data

TPSA 43.84
LogP 1.3617
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Key Words

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3-(Difluoromethyl)-1-methyl-1H-pyrazol-4-amine hydrochloride

CAS No. 1946817-21-5

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