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CS-W001157 4
Total: USD 88.00

4-(Difluoromethyl)aniline hydrochloride

  • CAS No. 1980063-54-4

  • Cat. No. CS-0018757
  • Purity≥95%
  • MDL No.MFCD28145075
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-(Difluoromethyl)aniline hydrochloride|CS-0018757

Structure of 1980063-54-4

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Description

4-(Difluoromethyl)aniline hydrochloride delivers a fluorinated aryl amine scaffold with enhanced metabolic stability and improved solubility under standard conditions. The difluoromethyl group imparts electron-withdrawing character, while the hydrochloride salt ensures robust handling and compatibility in synthetic workflows. This compound integrates efficiently into pharmaceutical intermediates and functional materials.

Application

4-(Difluoromethyl)aniline hydrochloride serves as a valuable building block for fluorinated aromatic scaffolds, enabling direct incorporation of a difluoromethyl group into pharmaceutical and agrochemical intermediates. The hydrochloride salt enhances bench stability and solubility, facilitating handling and purification in standard synthetic workflows. It participates reliably in nucleophilic substitution, coupling reactions, and heterocycle formation, offering predictable reactivity with good functional group tolerance.

General Information

  • CAS No. 1980063-54-4
  • Cat. No. CS-0018757
  • Purity ≥95%
  • MDL No. MFCD28145075
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈ClF₂N
  • Molecular Weight 179.59
  • Synonym(s) 4-(Difluoromethyl)benzenamine hydrochloride
  • SMILES NC1=CC=C(C(F)F)C=C1.[H]Cl

Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.6282
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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