Fmoc-D-Phe(3-F)-OH

Name: Fmoc-D-Phe(3-F)-OH
Brand: ChemScene
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CAS No. 198545-72-1
Cat. No. CS-W009713
Purity≥98%
MDL No.MFCD00672554

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

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Structure of 198545-72-1

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Description

Fmoc-D-Phe(3-F)-OH features a fluorinated phenyl ring at the meta position, enhancing electron-withdrawing character and metabolic stability. This derivative integrates readily into peptide chains under standard coupling conditions, offering improved solubility and reduced aggregation during synthesis. The Fmoc group enables efficient N-terminal protection and stepwise elongation in solid-phase peptide synthesis.

Application

Fmoc-D-Phe(3-F)-OH serves as a valuable building block in peptide synthesis, offering enhanced metabolic stability and modulated hydrophobicity through the meta-fluorinated phenyl side chain. The Fmoc group enables efficient N-terminal protection for solid-phase peptide synthesis, while the D-configuration imparts resistance to enzymatic degradation. This derivative facilitates the incorporation of fluorinated aromatic residues into bioactive peptides with improved membrane permeability and target binding affinity.

General Information

CAS No. 198545-72-1
Cat. No. CS-W009713
Purity ≥98%
MDL No. MFCD00672554
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₄H₂₀FNO₄
Molecular Weight 405.42
Synonym(s) None
SMILES O=C([C@H](NC(OCC1C2=CC=CC=C2C3=CC=CC=C13)=O)CC4=CC=CC(F)=C4)O

Computational Chemistry Data

TPSA 75.63
LogP 4.3601
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 6

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Other Classifications

Bioactive Molecules Peptides

Building Blocks Functional Group Fmoc

Life Science Amino Acids and their Derivatives Phenylalanine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Key Words

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Fmoc-D-Phe(3-F)-OH

CAS No. 198545-72-1

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