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Structure of 20295-34-5
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Cyclopropanecarbothioamide features a strained cyclopropyl ring fused to a thiocarbonyl-amide functional group, delivering high reactivity in transition-metal-catalyzed cycloadditions. The rigid scaffold enhances regioselectivity in synthetic transformations, while the thioamide moiety supports stable coordination to palladium and nickel complexes under standard conditions. This compound serves as a key intermediate in heterocycle synthesis and enables efficient access to bioactive thiazole derivatives.
Cyclopropanecarbothioamide serves as a versatile building block in medicinal chemistry, enabling the construction of thioamide-containing heterocycles and peptide mimetics. Its cyclopropyl ring imparts conformational rigidity and enhanced metabolic stability, while the thioamide group offers robust nucleophilicity and compatibility with standard coupling reactions. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis workflows in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302
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Precautionary Statements : P264-P270-P301+P310-P330-P501
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Lot numbers can be found on the outside label of a product: