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1-Aminopyrrolidin-2-one hydrochloride

  • CAS No. 20386-22-5

  • Cat. No. CS-D0019
  • Purity≥95%
  • MDL No.MFCD09258892

*For research and further manufacturing use only, not for direct human use.

1-Aminopyrrolidin-2-one hydrochloride|CS-D0019

Structure of 20386-22-5

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General Information

  • CAS No. 20386-22-5
  • Cat. No. CS-D0019
  • Purity ≥95%
  • MDL No. MFCD09258892
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₉ClN₂O
  • Molecular Weight 136.58
  • Synonym(s) N-Amino-2-pyrrolidinone hydrochloride; 2-Pyrrolidinone, 1-aMino-, hydrochloride
  • SMILES O=C1N(N)CCC1.[H]Cl

Description

1-Aminopyrrolidin-2-one hydrochloride offers a stable, moisture-tolerant platform for medicinal chemistry applications. This bench-stable derivative integrates readily into peptide-like scaffolds and delivers enhanced solubility in aqueous systems, facilitating efficient synthesis workflows in drug discovery pipelines.

Application

1-Aminopyrrolidin-2-one hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient access to saturated heterocyclic scaffolds. Its amine functionality facilitates direct derivatization and salt formation, enhancing solubility and handling. The molecule exhibits excellent bench stability and compatibility with standard coupling protocols, making it well-suited for modular synthesis of bioactive compounds and API intermediates.

Synthesis

  • Route1
    • 1-((Diphenylmethylene)amino)pyrrolidin-2-one|CS-0071021
      79289-48-8
    • ~81%
    • In-stock
      1-Aminopyrrolidin-2-one hydrochloride|CS-D0019
      20386-22-5

    References

    • ELI LILLY AND COMPANY Patent: WO2004/48383 A1, 2004 ; Location in patent: Page 39-40 ; WO 2004/048383 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.33
  • LogP   -0.0957
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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