5-Amino-1-methyl-2,3-dihydro-1H-indol-2-one

Name: 5-Amino-1-methyl-2,3-dihydro-1H-indol-2-one
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 20870-91-1
Cat. No. CS-0050693
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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5-Amino-1-methyl-2,3-dihydro-1H-indol-2-one|CS-0050693

Structure of 20870-91-1

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General Information

CAS No. 20870-91-1
Cat. No. CS-0050693
Purity ≥97%
MDL No. None
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₁₀N₂O
Molecular Weight 162.19
Synonym(s) 5-Amino-1-methyl-2-oxoindoline
SMILES CN1C(=O)CC2=CC(N)=CC=C12

Description

5-Amino-1-methyl-2,3-dihydro-1H-indol-2-one features a fused heterocyclic core with a strategically positioned amino group and methyl substitution, enabling direct incorporation into bioactive molecule scaffolds. This bench-stable intermediate delivers enhanced solubility and reactivity in synthetic pathways targeting indole-based pharmaceuticals and functional materials.

Application

5-Amino-1-methyl-2,3-dihydro-1H-indol-2-one serves as a versatile building block in medicinal chemistry, enabling the synthesis of indole-based scaffolds through standard functionalization and coupling reactions. Its amino and carbonyl groups provide orthogonal reactivity for late-stage diversification, while the methyl substituent enhances metabolic stability and modulates solubility. Bench-stable and readily purified by crystallization, it functions effectively in peptide coupling, Suzuki-Miyaura cross-coupling, and heterocycle formation workflows.

Synthesis

Route1
- 20870-89-7
- ~98%
- In-stock
  
  20870-91-1
References
- THE SCRIPPS RESEARCH INSTITUTE Patent: WO2008/115369 A2, 2008 ; Location in patent: Page/Page column 147 ; WO 2008/115369 A2
Route2
- In-stock
  
  61-70-1
- ~%
- In-stock
  
  20870-91-1
References
- Journal of the Chemical Society, , p. 620,621

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 46.33
LogP 0.7877
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Indolin compounds

Key Words

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5-Amino-1-methyl-2,3-dihydro-1H-indol-2-one

CAS No. 20870-91-1

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