(3-Fluorobicyclo[1.1.1]pentan-1-yl)methanamine hydrochloride

Name: (3-Fluorobicyclo[1.1.1]pentan-1-yl)methanamine hydrochloride
Brand: ChemScene
Availability: InStock
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CAS No. 2108917-20-8
Cat. No. CS-0370304
Purity≥98%
MDL No.None

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FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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(3-Fluorobicyclo[1.1.1]pentan-1-yl)methanamine hydrochloride|CS-0370304

Structure of 2108917-20-8

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Description

This bicyclic amine scaffold delivers a rigid, sterically constrained platform for medicinal chemistry optimization. The fluorinated cage imparts enhanced metabolic stability and modulates electronic properties, while the primary amine functionality enables straightforward conjugation. A bench-stable, moisture-tolerant building block for targeted ligand design.

Application

(3-Fluorobicyclo[1.1.1]pentan-1-yl)methanamine hydrochloride serves as a rigid, conformationally constrained amine building block for medicinal chemistry and target-oriented synthesis. Its trifluoromethyl-like steric profile and enhanced metabolic stability facilitate incorporation into bioactive molecules. The hydrochloride salt ensures excellent solubility and bench stability, enabling straightforward handling in standard amine coupling and reductive amination protocols.

General Information

CAS No. 2108917-20-8
Cat. No. CS-0370304
Purity ≥98%
MDL No. None
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₁ClFN
Molecular Weight 151.61
Synonym(s) (3-Fluoro-1-bicyclo[1.1.1]pentanyl)methanamine hydrochloride
SMILES NCC1(C2)CC2(F)C1.[H]Cl

Computational Chemistry Data

TPSA 26.02
LogP 1.2591
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Bridge Rings compounds Other bridge ring compounds

Key Words

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(3-Fluorobicyclo[1.1.1]pentan-1-yl)methanamine hydrochloride

CAS No. 2108917-20-8

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