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CS-W001157 4
Total: USD 88.00

2-cHloro-5-(fluorosulfonyl)benzoic acid

  • CAS No. 21346-66-7

  • Cat. No. CS-0230004
  • Molecule weight238.62
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-cHloro-5-(fluorosulfonyl)benzoic acid|CS-0230004

Structure of 21346-66-7

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General Information

  • CAS No. 21346-66-7
  • Cat. No. CS-0230004
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄ClFO₄S
  • Molecular Weight 238.62
  • Synonym(s) 2-chloro-5-(fluorosulpho)benzoic acid
  • SMILES O=C(O)C1=CC(S(=O)(F)=O)=CC=C1Cl

Description

2-Chloro-5-(fluorosulfonyl)benzoic acid features a fluorosulfonyl group that enhances electrophilicity for efficient acylation reactions. The chloro substituent provides steric and electronic modulation, while the carboxylic acid functionality enables direct coupling or derivatization. This compound offers high stability under standard bench conditions and serves as a key building block in bioconjugation and pharmaceutical synthesis.

Application

2-Chloro-5-(fluorosulfonyl)benzoic acid serves as a versatile building block for sulfonamide and sulfonyl fluoride synthesis, enabling efficient introduction of fluorosulfonyl groups into aromatic scaffolds. Its stability under standard reaction conditions and compatibility with diverse functional groups facilitate straightforward derivatization in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   71.44
  • LogP   1.6964
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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