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CS-W001157 4
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2-cHloro-5-(fluorosulfonyl)benzoic acid

  • CAS No. 21346-66-7

  • Cat. No. CS-0230004
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-cHloro-5-(fluorosulfonyl)benzoic acid|CS-0230004

Structure of 21346-66-7

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Description

2-Chloro-5-(fluorosulfonyl)benzoic acid features a fluorosulfonyl group that enhances electrophilicity for efficient acylation reactions. The chloro substituent provides steric and electronic modulation, while the carboxylic acid functionality enables direct coupling or derivatization. This compound offers high stability under standard bench conditions and serves as a key building block in bioconjugation and pharmaceutical synthesis.

Application

2-Chloro-5-(fluorosulfonyl)benzoic acid serves as a versatile building block for sulfonamide and sulfonyl fluoride synthesis, enabling efficient introduction of fluorosulfonyl groups into aromatic scaffolds. Its stability under standard reaction conditions and compatibility with diverse functional groups facilitate straightforward derivatization in medicinal chemistry and materials science applications.

General Information

  • CAS No. 21346-66-7
  • Cat. No. CS-0230004
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄ClFO₄S
  • Molecular Weight 238.62
  • Synonym(s) 2-chloro-5-(fluorosulpho)benzoic acid
  • SMILES O=C(O)C1=CC(S(=O)(F)=O)=CC=C1Cl

Computational Chemistry Data

  • TPSA   71.44
  • LogP   1.6964
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group :
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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