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CS-W001157 4
Total: USD 88.00

Pyridazine-3-carboxylic acid

  • CAS No. 2164-61-6

  • Cat. No. CS-W004823
  • Purity≥97%
  • MDL No.MFCD01646333

*For research and further manufacturing use only, not for direct human use.

Pyridazine-3-carboxylic acid|CS-W004823

Structure of 2164-61-6

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General Information

  • CAS No. 2164-61-6
  • Cat. No. CS-W004823
  • Purity ≥97%
  • MDL No. MFCD01646333
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄N₂O₂
  • Molecular Weight 124.10
  • Synonym(s) 3-pyridazinylcarboxylic acid
  • SMILES C1=C(N=NC=C1)C(O)=O

Description

Pyridazine-3-carboxylic acid features a rigid, electron-deficient heterocyclic core paired with a carboxylic acid group, enabling direct incorporation into bioactive scaffolds. This structure supports hydrogen bonding and metal coordination, enhancing binding affinity in medicinal chemistry applications. The compound exhibits bench-stable handling characteristics and compatibility with standard peptide coupling protocols.

Application

Pyridazine-3-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of heterocyclic scaffolds through standard amide coupling and cyclization protocols. Its carboxylic acid functionality facilitates direct derivatization or activation for peptide-like linkages, while the electron-deficient pyridazine core supports nucleophilic substitution and transition-metal-catalyzed cross-coupling reactions. The compound exhibits good bench stability and is readily purified by recrystallization, making it suitable for scalable synthesis and API intermediate development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   63.08
  • LogP   0.1748
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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