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Structure of 2167095-52-3
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This difluorocyclobutane carboxylic acid features a trifluoromethyl group that enhances metabolic stability and lipophilicity, while the strained cyclobutane ring imparts conformational rigidity. The geminal difluoro substitution increases electrophilicity at the adjacent carbon, enabling selective functionalization in medicinal chemistry applications.
3,3-Difluoro-1-(trifluoromethyl)cyclobutane-1-carboxylic acid serves as a rigid, electron-deficient building block for medicinal chemistry and agrochemical research. Its trifluoromethyl and difluorocyclobutane moieties confer enhanced metabolic stability and lipophilicity, enabling efficient incorporation into bioactive scaffolds. The carboxylic acid functionality facilitates direct coupling reactions and salt formation, supporting purification and derivatization in standard synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: