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Structure of 216959-91-0
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4-(Pyrimidin-5-yl)benzoic acid features a rigid, electron-deficient pyrimidine ring linked via a phenylene spacer to a carboxylic acid group. This structural motif enables integration into conjugated systems, enhancing planarity and enabling hydrogen bonding or π–π interactions in supramolecular assemblies. The compound serves as a versatile scaffold for pharmaceutical intermediates and functional materials requiring precise spatial orientation and polar functionality.
4-(Pyrimidin-5-yl)benzoic acid serves as a versatile building block for medicinal chemistry and materials science, enabling the construction of biologically active heterocyclic scaffolds. Its dual aromatic system—pyrimidine and benzene—confers enhanced planarity and π-stacking potential, while the carboxylic acid group facilitates direct coupling reactions or derivatization via amide, ester, or amidation protocols. The compound exhibits good bench stability and is readily purified by recrystallization, making it well-suited for high-throughput synthesis workflows and API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: