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CS-W001157 4
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(S)-3-Aminodihydrofuran-2(3H)-one

  • CAS No. 2185-02-6

  • Cat. No. CS-W011319
  • Purity≥97%
  • MDL No.MFCD18833624

*For research and further manufacturing use only, not for direct human use.

(S)-3-Aminodihydrofuran-2(3H)-one|CS-W011319

Structure of 2185-02-6

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General Information

  • CAS No. 2185-02-6
  • Cat. No. CS-W011319
  • Purity ≥97%
  • MDL No. MFCD18833624
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₇NO₂
  • Molecular Weight 101.11
  • Synonym(s) L-HOMOSERINE LACTONE, HYDROCHLORIDE
  • SMILES O=C1OCC[C@@H]1N

Description

Acyl-homoserine lactone signaling modulation via substrate-dependent synthase activity is mediated by L-Homoserine lactone hydrochloride (CAS 2185-02-6), enabling precise quorum sensing disruption in Gram-negative bacterial systems.

Application

L-Homoserine lactone hydrochloride (CAS 2185-02-6) inhibits arterial smooth muscle contraction by modulating intracellular calcium dynamics and disrupting signaling cascades linked to vascular tone regulation. It blocks sustained vasoconstriction. Researchers use this compound to probe mechanisms behind hypertension and endothelial dysfunction in preclinical models.

Synthesis

  • Route1

    References

    • Birnbaum; Greenstein Archives of Biochemistry, 1953 , vol. 42, p. 212,214 Full Text Show Details Kitagawa; Monobe Journal of Biochemistry (Tokyo, Japan), 1933 , vol. 18, p. 333,337 Nippon Nogei Kagaku Kaishi, 1933 , vol. 9, p. 845,848
  • Route2

    References

    • Bothwell, Ian R.; Luo, Minkui Organic Letters, 2014 , vol. 16, # 11 p. 3056 - 3059
  • Route3

    References

    • Box, David; Colclough, David; Gillies, Iain; Loft, Michael Simon; Moore, Rebecca Patent: US2004/87654 A1, 2004 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   -0.7394
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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