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Structure of 21943-12-4
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3-Bromopyrazin-2-amine delivers a reactive bromine handle adjacent to a pyrazine nitrogen, enabling direct functionalization in cross-coupling and nucleophilic substitution reactions. This bench-stable heterocycle integrates readily into complex scaffolds for medicinal chemistry and materials science applications.
3-Bromopyrazin-2-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions for the construction of biaryl and heteroaryl scaffolds. The bromine substituent provides high reactivity in Suzuki, Stille, and Negishi couplings, while the pyrazin-2-amine moiety offers a rigid, electron-deficient core compatible with diverse functional groups. Its bench-stable solid form facilitates handling and purification, making it well-suited for iterative synthesis campaigns targeting kinase inhibitors and other nitrogen-containing pharmaceuticals.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: