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Structure of 231291-22-8
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6-(Trifluoromethyl)nicotinic acid features a trifluoromethyl group at the 6-position of the nicotinic acid scaffold, imparting enhanced electron-withdrawing character and metabolic stability. This structural motif enables direct incorporation into bioactive molecules, particularly in medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds. The compound exhibits excellent bench stability and solubility in common organic solvents, facilitating efficient coupling reactions under standard conditions.
6-(Trifluoromethyl)nicotinic acid serves as a valuable building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, while the carboxylic acid functionality facilitates direct coupling reactions or derivatization. The compound exhibits good bench stability and is compatible with standard synthetic protocols, making it a practical choice for constructing complex scaffolds in drug discovery workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: