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CS-W001157 4
Total: USD 88.00

Boc-Guanidine

  • CAS No. 219511-71-4

  • Cat. No. CS-W022603
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Boc-Guanidine|CS-W022603

Structure of 219511-71-4

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General Information

  • CAS No. 219511-71-4
  • Cat. No. CS-W022603
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₃N₃O₂
  • Molecular Weight 159.19
  • Synonym(s) tert-Butyl carbamimidoylcarbamate; Boc-Guanidine
  • SMILES O=C(OC(C)(C)C)NC(N)=N

Description

Boc-Guanidine delivers a protected guanidine moiety for synthetic applications in peptide chemistry and medicinal discovery. This bench-stable, moisture-tolerant reagent integrates readily into complex scaffolds, enabling efficient access to functionalized amidine derivatives under standard conditions.

Application

Boc-Guanidine serves as a stable, bench-ready building block for the synthesis of guanidine-containing scaffolds in medicinal chemistry and peptide modification. It functions as a protected guanidine equivalent, enabling selective introduction of the guanidine group under mild deprotection conditions. The Boc group ensures excellent functional group tolerance and simplifies purification, making it ideal for use in multi-step syntheses and heterocycle construction.

Synthesis

  • Route1

    References

    • Schmuck, Carsten; Bickert, Volker; Merschky, Michael; Geiger, Lars; Rupprecht, Daniel; Dudaczek, Juergen; Wich, Peter; Rehm, Thomas; Machon, Uwe European Journal of Organic Chemistry, 2008 , # 2 p. 324 - 329
  • Route2
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • null|null
      124-46-9
    • ~89%
    • In-stock
      Boc-Guanidine|CS-W022603
      219511-71-4

    References

    • Abou-Jneid, Robert; Ghoulami, Said; Martin, Marie-Therese; Dau, Elise Tran Huu; Travert, Nathalie; Al-Mourabit, Ali Organic Letters, 2004 , vol. 6, # 22 p. 3933 - 3936
  • Route3

    References

    • The Regents of the University of California Patent: US6072075 A1, 2000 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   88.2
  • LogP   0.40457
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   0

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