3-Methoxybicyclo[1.1.1]pentan-1-amine hydrochloride

Name: 3-Methoxybicyclo[1.1.1]pentan-1-amine hydrochloride
Brand: ChemScene
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CAS No. 2197502-05-7
Cat. No. CS-0167520
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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3-Methoxybicyclo[1.1.1]pentan-1-amine hydrochloride|CS-0167520

Structure of 2197502-05-7

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Description

3-Methoxybicyclo[1.1.1]pentan-1-amine hydrochloride features a rigid, strained bicyclic core that imparts exceptional metabolic stability and conformational restraint. The methoxy group enhances solubility and modulates electronic properties, while the protonated amine ensures high water solubility and salt stability. This compound serves as a valuable scaffold in medicinal chemistry for probing steric and electronic effects in bioactive molecule design.

Application

3-Methoxybicyclo[1.1.1]pentan-1-amine hydrochloride serves as a rigid, conformationally constrained amine building block for medicinal chemistry and synthetic organic applications. Its bicyclic scaffold imparts enhanced metabolic stability and defined spatial orientation, facilitating precise pharmacophore positioning. The methoxy group provides moderate polarity and handles well under standard coupling conditions, while the hydrochloride salt ensures excellent solubility and bench stability. Functions effectively in amide bond formation, reductive amination, and transition-metal-catalyzed cross-couplings, enabling efficient access to complex heterocyclic scaffolds and API intermediates.

General Information

CAS No. 2197502-05-7
Cat. No. CS-0167520
Purity ≥98%
MDL No. None
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₂ClNO
Molecular Weight 149.62
Synonym(s) 3-Methoxy-bicyclo[1.1.1]pent-1-ylamine hydrochloride
SMILES NC1(C2)CC2(OC)C1.[H]Cl

Computational Chemistry Data

TPSA 35.25
LogP 0.6884
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Skeleton Fatty ring compounds Cyclobutane compounds

Building Blocks Skeleton Bridge Rings compounds Other bridge ring compounds

Key Words

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3-Methoxybicyclo[1.1.1]pentan-1-amine hydrochloride

CAS No. 2197502-05-7

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