4-Chloro-N-methylpicolinamide

Name: 4-Chloro-N-methylpicolinamide
Brand: ChemScene
Availability: InStock
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CAS No. 220000-87-3
Cat. No. CS-M2758
Purity≥98%
MDL No.MFCD02185921

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Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 220000-87-3

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Description

4-Chloro-N-methyl-2-pyridinecarboxamide features a chlorinated pyridine core with a methylated amide group, delivering enhanced metabolic stability and improved membrane permeability. This configuration supports efficient integration into bioactive scaffolds for medicinal chemistry applications, particularly in kinase inhibitor development and CNS-targeted drug discovery.

Application

4-Chloro-N-methyl-2-pyridinecarboxamide serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based scaffolds. Its chloro group facilitates nucleophilic substitution and palladium-catalyzed coupling reactions, while the N-methyl amide provides stability and favorable solubility. This compound demonstrates excellent bench stability and functional group tolerance, making it well-suited for iterative synthesis and scale-up in API development workflows.

General Information

CAS No. 220000-87-3
Cat. No. CS-M2758
Purity ≥98%
MDL No. MFCD02185921
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₇ClN₂O
Molecular Weight 170.60
Synonym(s) None
SMILES ClC1=CC(C(NC)=O)=NC=C1

Computational Chemistry Data

TPSA 41.99
LogP 1.0946
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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4-Chloro-N-methylpicolinamide

CAS No. 220000-87-3

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