4,5-Dichloro-2-iodoaniline

Name: 4,5-Dichloro-2-iodoaniline
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 220185-63-7
Cat. No. CS-B1163
Purity≥97%
MDL No.MFCD28128363

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 220185-63-7

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 220185-63-7
Cat. No. CS-B1163
Purity ≥97%
MDL No. MFCD28128363
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄Cl₂IN
Molecular Weight 287.91
Synonym(s) 4,5-dichloro-2-iodobenzenaMine
SMILES NC1=CC(Cl)=C(Cl)C=C1I

Description

4,5-Dichloro-2-iodoaniline features a trihalogenated aromatic core with orthogonal reactivity at the iodine and amine sites. This electron-deficient aniline derivative enables direct coupling in cross-coupling protocols and serves as a key intermediate in the synthesis of functionalized heterocycles and bioactive molecules under standard conditions.

Application

4,5-Dichloro-2-iodoaniline serves as a versatile building block for the synthesis of biologically active heterocycles and pharmaceutical intermediates. Its ortho-iodo functionality enables palladium-catalyzed cross-coupling reactions under standard conditions, while the flanking dichloro substituents provide enhanced electronic tuning and metabolic stability. The compound exhibits good bench stability and facilitates efficient functionalization in late-stage diversification workflows.

Synthesis

Route1
- 95-76-1
- ~82%
- In-stock
  
  220185-63-7
References
- Li, Xiaoyan; Yin, Wenyuan; Sarma, P.V.V. Srirama; Zhou, Hao; Jun Ma; Cook, James M. Tetrahedron Letters, 2004 , vol. 45, # 46 p. 8569 - 8573
Route2
- 95-76-1
- ~75%
- In-stock
  
  835595-11-4
- 89284-72-0
- In-stock
  
  220185-63-7
References
- Joshi, Sudhir N.; Vyas, Sandhya M.; Wu, Huimin; Duffel, Michael W.; Parkin, Sean; Lehmler, Hans-Joachim Tetrahedron, 2011 , vol. 67, # 39 p. 7461 - 7469

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 26.02
LogP 3.1802
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Iodide

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

4,5-Dichloro-2-iodoaniline sigma4,5-Dichloro-2-iodoaniline manufacturer4,5-Dichloro-2-iodoaniline price4,5-Dichloro-2-iodoaniline structure4,5-Dichloro-2-iodoaniline SDSbuy 4,5-Dichloro-2-iodoaniline4,5-Dichloro-2-iodoaniline supplier4,5-Dichloro-2-iodoaniline uses4,5-Dichloro-2-iodoaniline molecular weightprice of 4,5-Dichloro-2-iodoaniline4,5-Dichloro-2-iodoaniline chemical name formula of 4,5-Dichloro-2-iodoaniline

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

4,5-Dichloro-2-iodoaniline

CAS No. 220185-63-7

Recommended Products