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Structure of 22287-35-0
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Bicyclo[1.1.1]pentan-1-amine hydrochloride features a rigid, strain-engineered cage framework that imparts exceptional thermal and metabolic stability. This bench-stable derivative serves as a privileged scaffold in medicinal chemistry, enabling efficient incorporation of nitrogen functionality into bioactive molecules with enhanced membrane permeability and target engagement.
Bicyclo[1.1.1]pentan-1-amine hydrochloride serves as a rigid, conformationally constrained amine building block for medicinal chemistry and catalysis. Its stable, sterically encumbered scaffold enables precise spatial positioning of functional groups, enhancing target binding affinity in drug discovery. The hydrochloride salt improves solubility and handling, facilitating purification and incorporation into diverse synthetic sequences including amide couplings and reductive aminations.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: