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CS-W001157 4
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Pomalidomide-piperazine hydrochloride

  • CAS No. 2230956-83-7

  • Cat. No. CS-0906716
  • Purity≥98%
  • MDL No.MFCD32898792

*For research and further manufacturing use only, not for direct human use.

Pomalidomide-piperazine hydrochloride|CS-0906716

Structure of 2230956-83-7

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General Information

  • CAS No. 2230956-83-7
  • Cat. No. CS-0906716
  • Purity ≥98%
  • MDL No. MFCD32898792
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₁₉ClN₄O₄
  • Molecular Weight 378.81
  • Synonym(s) None
  • SMILES O=C1NC(C(CC1)N2C(C3=CC=CC(N4CCNCC4)=C3C2=O)=O)=O.Cl

Description

Pomalidomide-piperazine (hydrochloride) features a piperazine-linked derivative of pomalidomide, enhancing solubility and modulating pharmacokinetic properties. This analog integrates the immunomodulatory framework with a polar piperazine moiety, enabling improved handling in aqueous systems. The hydrochloride salt ensures stability and facilitates formulation under standard bench conditions.

Application

Pomalidomide-piperazine (hydrochloride) serves as a key intermediate in the synthesis of immunomodulatory drug candidates, leveraging the established reactivity of the phthalimide core and piperazine nitrogen for downstream functionalization. Its hydrochloride salt enhances solubility and stability under standard bench conditions, facilitating purification and integration into multi-step synthetic sequences. Functions as a building block for targeted heterocyclic architectures relevant to oncology research.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   98.82
  • LogP   -0.3651
  • H_Acceptors   8
  • H_Donors   2
  • Rotatable_Bonds   2

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