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CS-W001157 4
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2-Bromoisophthalic acid

  • CAS No. 22433-91-6

  • Cat. No. CS-0168202
  • Purity≥95%
  • MDL No.MFCD00099229
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Bromoisophthalic acid|CS-0168202

Structure of 22433-91-6

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Description

2-Bromoisophthalic acid features a bromine substituent at the aromatic ring, enhancing its reactivity in cross-coupling transformations. This ortho-disubstituted benzoic acid derivative offers improved solubility and stability compared to non-halogenated analogs, facilitating efficient incorporation into pharmaceutical intermediates and functional materials under standard conditions.

Application

2-Bromoisophthalic acid serves as a versatile building block in synthetic organic chemistry, enabling direct functionalization at the aromatic ring and carboxylic acid termini. Its bromine substituent facilitates palladium-catalyzed cross-coupling reactions, while the ortho-dicarboxylic acid framework supports metal coordination and derivatization for heterocycle synthesis. The compound exhibits good bench stability and is readily purified by recrystallization, making it well-suited for use in medicinal chemistry lead optimization and materials science applications.

General Information

  • CAS No. 22433-91-6
  • Cat. No. CS-0168202
  • Purity ≥95%
  • MDL No. MFCD00099229
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrO₄
  • Molecular Weight 245.03
  • Synonym(s) 2-Bromobenzene-1,3-dicarboxylic acid
  • SMILES O=C(O)C1=CC=CC(C(=O)O)=C1Br

Computational Chemistry Data

  • TPSA   74.6
  • LogP   1.8455
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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