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Structure of 22445-41-6
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1-Iodo-3,5-dimethylbenzene (5-Iodo-m-xylene) is an aryl halide. It can be obtained from 5-bromo-m-xylene, via copper-catalyzed halogen exchange reaction, in the presence of NaI or KI in n-BuOH or DMF (solvents). It undergoes reaction with phenol in the presence of CuFe2O4 nano powder as a recyclable catalyst to afford 1,3-dimethyl-5-phenoxybenzene.1-Iodo-3,5-dimethylbenzene (5-iodo-m-xylene) is suitable for use in the synthesis of N-(3,5-xylyl)-N-ethylaniline, an arylamine.It may be used in the following studies:-Arylation of ketones.Copper-catalyzed N-arylation of imidazoles.Cyanation of 5-iodo-m-xylene to form 3,5-dimethylbenzonitrile.Synthesis of 1,3-Dimethyl-5-phenoxybenzene by nano-CuFe2O4 catalyzed C-O cross-coupling with phenol.CuBr-catalyzed amination of 1-iodo-3,5-dimethylbenzene to form N-Allyl-3,5-dimethylbenzenamine.Copper-catalyzed C-S bond-formation between 5-iodo-m-xylene and thiophenol.As a starting material in the synthesis of biphenyl-3,3,5,5-tetracarboxylic acid.Radical bromination of 5-iodo-m-xylene by N-bromosuccinimide to form 1,3-bis(bromomethyl)-5-iodobenzene.
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GHS Pictogram :
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GHS No : GHS07,GHS08,GHS09
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Signal Word : Danger
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UN#: 3082
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Class : 9
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Packing Group : Ⅲ
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Hazard Statements : H315-H319-H332-H334-H335-H336-H411
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Precautionary Statements : P260-P261-P264-P270-P271-P273-P280-P285-P302+P352-P304+P340-P304+P341-P305+P351+P338-P312-P332+P313-P337+P313-P342+P311-P362+P364-P391-P403+P233-P405-P501
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