Desamino lenalidomide-CH2NH2 hydrochloride

Name: Desamino lenalidomide-CH2NH2 hydrochloride
Brand: ChemScene
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CAS No. 2248702-12-5
Cat. No. CS-0637628
Purity≥95%
MDL No.MFCD31746004

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Desamino lenalidomide-CH2NH2 hydrochloride|CS-0637628

Structure of 2248702-12-5

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Description

This piperidine-dione derivative features a strategically positioned aminomethyl group on the isoindolinone scaffold, enabling direct conjugation or functionalization. The hydrochloride salt enhances solubility and stability under standard conditions, facilitating use in synthetic workflows requiring precise amine handling.

Application

3-(6-(Aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride serves as a key heterocyclic building block for medicinal chemistry campaigns, enabling efficient access to isoindolinone-based scaffolds. The amine-functionalized side chain facilitates conjugation and derivatization, while the diketopiperazine core provides structural rigidity and enhanced metabolic stability. Bench-stable and compatible with standard purification methods, it functions effectively in peptide coupling, reductive amination, and macrocyclization workflows.

General Information

CAS No. 2248702-12-5
Cat. No. CS-0637628
Purity ≥95%
MDL No. MFCD31746004
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₄H₁₆ClN₃O₃
Molecular Weight 309.75
Synonym(s) None
SMILES O=C1NC(C(CC1)N2C(C3=CC(CN)=CC=C3C2)=O)=O.Cl

Computational Chemistry Data

TPSA 92.5
LogP -1.0561
H_Acceptors 6
H_Donors 2
Rotatable_Bonds 2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Indolin compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Life Science PROTAC Ligands for E3 Ligase

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

Key Words

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Desamino lenalidomide-CH2NH2 hydrochloride

CAS No. 2248702-12-5

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