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CS-W001157 4
Total: USD 88.00

7-Chloro-1,3-dioxaindane-5-carboxylic acid

  • CAS No. 22519-35-3

  • Cat. No. CS-0225097
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7-Chloro-1,3-dioxaindane-5-carboxylic acid|CS-0225097

Structure of 22519-35-3

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General Information

  • CAS No. 22519-35-3
  • Cat. No. CS-0225097
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅ClO₄
  • Molecular Weight 200.58
  • Synonym(s) None
  • SMILES O=C(C1=CC2=C(OCO2)C(Cl)=C1)O

Description

7-Chloro-1,3-dioxaindane-5-carboxylic acid features a rigid, electron-deficient dioxaindane core that enhances metabolic stability and facilitates efficient coupling in synthetic transformations. This bench-stable scaffold integrates readily into complex molecular architectures, offering predictable reactivity under standard conditions.

Application

7-Chloro-1,3-dioxaindane-5-carboxylic acid serves as a versatile building block for heterocyclic synthesis, particularly in the construction of biologically relevant indoline and indole scaffolds. The molecule combines a stable dioxane-fused indane core with a carboxylic acid functionality that enables direct coupling reactions or derivatization. Its chlorine substituent provides a handle for further functionalization via nucleophilic substitution or transition-metal-catalyzed processes. The compound exhibits good bench stability and facilitates straightforward purification, making it suitable for iterative synthetic campaigns in medicinal chemistry and process development.

Safety Information

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Computational Chemistry Data

  • TPSA   55.76
  • LogP   1.7669
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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