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CS-W001157 4
Total: USD 88.00

Methyl 5-aminofuran-2-carboxylate

  • CAS No. 22600-30-2

  • Cat. No. CS-0049008
  • Purity≥97%
  • MDL No.MFCD00051661

*For research and further manufacturing use only, not for direct human use.

Methyl 5-aminofuran-2-carboxylate|CS-0049008

Structure of 22600-30-2

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General Information

  • CAS No. 22600-30-2
  • Cat. No. CS-0049008
  • Purity ≥97%
  • MDL No. MFCD00051661
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇NO₃
  • Molecular Weight None
  • Synonym(s) METHYL 5-AMINO-2-FUROATE
  • SMILES COC(=O)C1=CC=C(N)O1

Description

Methyl 5-aminofuran-2-carboxylate is a bench-stable heterocyclic building block featuring a strategically positioned amino group and ester functionality. This combination enables direct incorporation into diverse synthetic sequences, particularly in the development of bioactive molecules and pharmaceutical intermediates.

Application

Methyl 5-aminofuran-2-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to substituted furan derivatives. The amino group facilitates electrophilic substitution and transition-metal-catalyzed coupling reactions, while the ester function supports selective transformations. Its bench-stable nature and compatibility with common protecting group strategies make it well-suited for iterative synthesis in medicinal chemistry and process development workflows.

Synthesis

  • Route1
    • Methyl 5-nitrofuran-2-carboxylate|CS-0048963
      1874-23-3
    • ~88%
    • In-stock
      Methyl 5-aminofuran-2-carboxylate|CS-0049008
      22600-30-2

    References

    • Rahaim Jr., Ronald J.; Maleczka Jr., Robert E. Synthesis, 2006 , # 19 p. 3316 - 3340
  • Route2

    References

    • Journal of Organic Chemistry, , vol. 62, # 12 p. 4088 - 4096
  • Route3
    • Methyl 5-nitrofuran-2-carboxylate|CS-0048963
      1874-23-3
    • ~%
    • In-stock
      Methyl 5-aminofuran-2-carboxylate|CS-0049008
      22600-30-2
    • null|null
      83329-44-6

    References

    • Chemical and Pharmaceutical Bulletin, , vol. 30, # 7 p. 2647 - 2650

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   65.46
  • LogP   0.6484
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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