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CS-W001157 4
Total: USD 88.00

2-(4-Aminophenoxy)acetic acid

  • CAS No. 2298-36-4

  • Cat. No. CS-0199636
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(4-Aminophenoxy)acetic acid|CS-0199636

Structure of 2298-36-4

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General Information

  • CAS No. 2298-36-4
  • Cat. No. CS-0199636
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉NO₃
  • Molecular Weight 167.16
  • Synonym(s) TIMTEC-BB SBB001635
  • SMILES C1=C(C=CC(=C1)OCC(=O)O)N

Description

2-(4-Aminophenoxy)acetic acid features a phenolic ether linkage with a pendant amino group, enabling conjugation and bioconjugation applications. The molecule combines amine functionality with a polar, aromatic scaffold, offering enhanced solubility and reactivity in aqueous environments. This structure facilitates integration into peptide and polymer systems under mild conditions.

Application

2-(4-Aminophenoxy)acetic acid serves as a versatile building block for pharmaceutical and agrochemical synthesis, enabling efficient construction of bioactive heterocycles and peptide conjugates. Its phenolic ether linkage and pendant amine facilitate selective derivatization, while the carboxylic acid group supports direct coupling or salt formation. The compound exhibits good bench stability and is readily purified by recrystallization, making it well-suited for iterative synthetic workflows in medicinal chemistry and process development.

Synthesis

  • Route1
    • In-stock
      Acetaminophen|CS-2819
      103-90-2
    • null|null
      3926-62-3
    • ~%
    • In-stock
      2-(4-Aminophenoxy)acetic acid|CS-0199636
      2298-36-4

    References

    • US6559292 B1, ; US6689201 B1, ;
  • Route2

    References

    • Journal fuer Praktische Chemie (Leipzig), , vol. <2> 55, p. 122 Journal fuer Praktische Chemie (Leipzig), , vol. <2> 20, p. 283
  • Route3
    • null|null
      901451-30-7
    • ~%
    • In-stock
      2-(4-Aminophenoxy)acetic acid|CS-0199636
      2298-36-4

    References

    • US2006/172983 A1, ; Page/Page column 31 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   72.55
  • LogP   0.7322
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   3

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