E3 ligase Ligand 63

Name: E3 ligase Ligand 63
Brand: ChemScene
Availability: InStock
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CAS No. 2304754-51-4
Cat. No. CS-0158732
Molecule weight338.16
Purity≥98%
MDL No.MFCD34183045

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 2304754-51-4
Cat. No. CS-0158732
Purity ≥98%
MDL No. MFCD34183045
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₁₂BrN₃O₃
Molecular Weight 338.16
Synonym(s) None
SMILES O=C(C(N1C2=CC=CC(Br)=C2N(C)C1=O)CC3)NC3=O

Description

E3 ligase Ligand 63 is a potent, cell-permeable modulator designed to engage specific E3 ubiquitin ligases for targeted protein degradation. This small molecule features a unique scaffold that enables selective recruitment of the ligase complex, facilitating efficient ubiquitination and proteasomal processing of disease-relevant targets. Its stability under physiological conditions supports reliable use in cellular assays and target validation workflows.

Application

E3 ligase Ligand 63 serves as a well-characterized molecular scaffold for targeted protein degradation, enabling efficient recruitment of E3 ubiquitin ligases in PROTAC®-based strategies. Its defined functional groups support orthogonal conjugation and demonstrate robust stability under physiological conditions, facilitating reliable synthesis and purification. This compound functions as a key warhead component in bifunctional degraders, offering high selectivity and compatibility with standard medicinal chemistry workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

TPSA 73.1
LogP 1.0802
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Benzimidazole compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Life Science PROTAC Ligands for E3 Ligase

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

Key Words

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E3 ligase Ligand 63

CAS No. 2304754-51-4

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