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(3S,4R)-3-Fluoro-1-methylpiperidin-4-amine dihydrochloride

  • CAS No. 2306246-40-0

  • Cat. No. CS-0527834
  • Molecule weight205.10
  • Purity≥96%
  • MDL No.MFCD31743843

*For research and further manufacturing use only, not for direct human use.

(3S,4R)-3-Fluoro-1-methylpiperidin-4-amine dihydrochloride|CS-0527834

Structure of 2306246-40-0

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General Information

  • CAS No. 2306246-40-0
  • Cat. No. CS-0527834
  • Purity ≥96%
  • MDL No. MFCD31743843
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₅Cl₂FN₂
  • Molecular Weight 205.10
  • Synonym(s) None
  • SMILES F[C@@H]1[C@@H](CCN(C1)C)N.Cl.Cl

Description

This dihydrochloride salt features a chiral piperidine core with fluorine at the 3-position and a methyl group at nitrogen, delivering enhanced metabolic stability and improved membrane permeability. The protonated amine centers ensure high solubility in aqueous media, facilitating use in medicinal chemistry workflows. Designed for efficient incorporation into bioactive molecules, this scaffold supports rapid structure-activity optimization in CNS-targeted drug discovery.

Application

(3S,4R)-3-Fluoro-1-methylpiperidin-4-amine dihydrochloride serves as a key chiral building block in medicinal chemistry, enabling the construction of fluorinated piperidine scaffolds prevalent in bioactive molecules. Its defined stereochemistry and protonatable nitrogen atoms facilitate efficient incorporation into drug candidates via standard amine coupling and reductive amination protocols. The dihydrochloride salt enhances solubility and stability for handling and purification, supporting robust performance in multi-step syntheses and scale-up processes.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   29.26
  • LogP   0.8309
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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