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Structure of 23872-36-8
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4-Chloro-1H-indole-3-carboxylic acid features a chlorine substituent at the 4-position of the indole core, enhancing electronic and metabolic stability. This bench-stable derivative integrates readily into pharmaceutical scaffolds, offering a polar, electron-deficient handle for coupling reactions and bioactive molecule design.
4-Chloro-1H-indole-3-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation into indole-based scaffolds common in kinase inhibitors and CNS-targeted compounds. The carboxylic acid group facilitates amide coupling, esterification, and metal-catalyzed transformations, while the 4-chloro substituent provides a handle for palladium-mediated cross-coupling reactions. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step syntheses requiring functional group compatibility and predictable reactivity.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: