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CS-W001157 4
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2-[(4R)-4-tert-Butyl-4,5-dihydro-2-oxazolyl]pyridine

  • CAS No. 242482-28-6

  • Cat. No. CS-0087140
  • Molecule weight204.27
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-[(4R)-4-tert-Butyl-4,5-dihydro-2-oxazolyl]pyridine|CS-0087140

Structure of 242482-28-6

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General Information

  • CAS No. 242482-28-6
  • Cat. No. CS-0087140
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₆N₂O
  • Molecular Weight 204.27
  • Synonym(s) 2-[(4R)-4-tert-Butyl-4,5-dihydro-2-oxazolyl]pyridine
  • SMILES CC(C)(C)[C@H](CO1)N=C1C2=NC=CC=C2

Description

(R)-tBu-Pyox is a bench-stable, sterically hindered chiral ligand featuring a pyridoxal-derived core. This configuration enables effective asymmetric induction in transition-metal-catalyzed transformations, particularly in enantioselective allylation and conjugate addition reactions. The tert-butyl group enhances solubility and reduces background reactivity.

Application

(R)-tBu-Pyox serves as a highly effective chiral ligand in asymmetric transition-metal catalysis, particularly enabling enantioselective C–C bond formations. Its robust pyridine-oxazoline scaffold offers excellent stereocontrol, bench stability, and compatibility with palladium and nickel systems. The tert-butyl group enhances steric differentiation and solubility, facilitating purification and scalability in synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

  • TPSA   34.48
  • LogP   2.2731
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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