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CS-W001157 4
Total: USD 88.00

Boc-Glu-OtBu

  • CAS No. 24277-39-2

  • Cat. No. CS-W007354
  • Purity≥97%
  • MDL No.MFCD00038273

*For research and further manufacturing use only, not for direct human use.

Boc-Glu-OtBu|CS-W007354

Structure of 24277-39-2

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General Information

  • CAS No. 24277-39-2
  • Cat. No. CS-W007354
  • Purity ≥97%
  • MDL No. MFCD00038273
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₅NO₆
  • Molecular Weight 303.35
  • Synonym(s) None
  • SMILES O=C(CC[C@@H](C(OC(C)(C)C)=O)NC(OC(C)(C)C)=O)O

Description

Boc-Glu-OtBu serves as a protected glutamic acid derivative, featuring a tert-butoxycarbonyl group at the α-amino position and a tert-butyl ester at the side-chain carboxyl. This dual protection enables stable incorporation into peptide synthesis sequences under standard conditions, facilitating selective deprotection and efficient coupling workflows in solid-phase and solution-phase methodologies.

Synthesis

  • Route1

    References

    • More, Swati S.; Vince, Robert Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 13 p. 3793 - 3797
  • Route2
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • null|null
      611182-62-8
    • ~91%
    • In-stock
      Boc-Glu-OtBu|CS-W007354
      24277-39-2

    References

    • Ohshima, Takashi; Gnanadesikan, Vijay; Shibuguchi, Tomoyuki; Fukuta, Yuhei; Nemoto, Tetsuhiro; Shibasaki, Masakatsu Journal of the American Chemical Society, 2003 , vol. 125, # 37 p. 11206 - 11207
  • Route3

    References

    • Avent, Anthony G.; Duggan, Heather M. E.; Young, Douglas W. Organic and Biomolecular Chemistry, 2005 , vol. 3, # 12 p. 2327 - 2332

Safety Information

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GHS Pictogram : N/A
GHS No : N/A
Signal Word : N/A
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

Quality Control

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Computational Chemistry Data

  • TPSA   101.93
  • LogP   2.0862
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   5

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