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CS-W001157 4
Total: USD 88.00

4-Morpholinoaniline

  • CAS No. 2524-67-6

  • Cat. No. CS-M0409
  • Purity≥97%
  • MDL No.MFCD00006169

*For research and further manufacturing use only, not for direct human use.

4-Morpholinoaniline|CS-M0409

Structure of 2524-67-6

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General Information

  • CAS No. 2524-67-6
  • Cat. No. CS-M0409
  • Purity ≥97%
  • MDL No. MFCD00006169
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₄N₂O
  • Molecular Weight 178.23
  • Synonym(s) None
  • SMILES NC1=CC=C(N2CCOCC2)C=C1

Description

4-Morpholinoaniline features a morpholine ring attached para to an amino group on benzene, delivering enhanced solubility and electron-donating character. This structure enables efficient integration into pharmaceutical intermediates and functional materials, particularly in dye synthesis and polymer modification. The compound exhibits robust stability under standard conditions.

Application

4-Morpholinoaniline serves as a versatile building block in medicinal chemistry, enabling the construction of diverse heterocyclic scaffolds and bioactive molecules. Its aniline functionality facilitates direct coupling reactions, while the morpholine ring provides enhanced solubility and hydrogen-bonding capacity. The compound exhibits good bench stability and compatibility with standard synthetic protocols, supporting efficient purification and integration into multi-step syntheses.

Synthesis

  • Route1

    References

    • US2013/45977 A1, ; Paragraph 0215; 0216; 0217; 0218 ;
  • Route2

    References

    • Organic Letters, , vol. 15, # 14 p. 3734 - 3737
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 48, # 26 p. 8261 - 8269

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.49
  • LogP   1.1054
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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