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Structure of 252882-61-4
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Spiro[indoline-3,4'-piperidin]-2-one delivers a rigid, three-dimensional scaffold ideal for medicinal chemistry. This spirocyclic core integrates a nitrogen-rich piperidine moiety with an indoline framework, enhancing target engagement and metabolic stability. The ketone functionality at the spiro junction enables direct derivatization, supporting rapid library expansion in drug discovery campaigns.
Spiro[indoline-3,4'-piperidin]-2-one serves as a versatile scaffold in medicinal chemistry, enabling efficient construction of complex alkaloid-like architectures. Its spirocyclic core provides rigidity and defined stereochemistry, while the ketone functionality supports selective reductions, nucleophilic additions, and further functionalization. The molecule exhibits good bench stability and compatibility with standard synthetic transformations, facilitating its use in lead optimization campaigns and heterocycle diversification.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: