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CS-W001157 4
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7-Aminoindolin-2-one

  • CAS No. 25369-32-8

  • Cat. No. CS-0188260
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7-Aminoindolin-2-one|CS-0188260

Structure of 25369-32-8

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General Information

  • CAS No. 25369-32-8
  • Cat. No. CS-0188260
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈N₂O
  • Molecular Weight 148.16
  • Synonym(s) None
  • SMILES O=C1NC=2C(N)=CC=CC2C1

Description

7-Aminoindolin-2-one delivers a reactive amine handle within a stable, planar heterocyclic scaffold. This core integrates readily into peptide conjugates and bioconjugation workflows, leveraging its solubility and compatibility with standard synthetic conditions. The electron-rich amine enables efficient coupling reactions without requiring protective group manipulation.

Application

7-Aminoindolin-2-one serves as a versatile building block in medicinal chemistry, enabling the synthesis of diverse heterocyclic scaffolds through standard amine functionalization and electrophilic substitution reactions. Its stability under routine bench conditions and compatibility with common coupling protocols facilitate efficient access to complex molecular architectures relevant to kinase inhibitor development and other bioactive compound classes.

Synthesis

  • Route1

    References

    • Khanwelkar, Rahul R.; Chen, Grace Shiahuy; Wang, Hsiao-Chun; Yu, Chao-Wu; Huang, Chiung-Hua; Lee, On; Chen, Chih-Hung; Hwang, Chrong-Shiong; Ko, Ching-Huai; Chou, Nien-Tzu; Lin, Mai-Wei; Wang, Ling-Mei; Chen, Yen-Chun; Hseu, Tzong-Hsiung; Chang, Chia-Ni; Hsu, Hui-Chun; Lin, Hui-Chi; Shih, Ying-Chu; Chou, Shuen-Hsiang; Tseng, Hsiang-Wen; Liu, Chih-Peng; Tu, Chia-Mu; Hu, Tsan-Lin; Tsai, Yuan-Jang; Chern, Ji-Wang Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 13 p. 4674 - 4686
  • Route2

    References

    • Owa, Takashi; Okauchi, Tatsuo; Yoshimatsu, Kentaro; Sugi, Naoko Hata; Ozawa, Yoichi; Nagasu, Takeshi; Koyanagi, Nozomu; Okabe, Tadashi; Kitoh, Kyosuke; Yoshino, Hiroshi Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 11 p. 1223 - 1226

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   0.7634
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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