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Structure of 2548-29-0
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3-Chlorosulfonyl-4-methylbenzoic acid features a chlorosulfonyl group flanked by a methyl-substituted aromatic ring and a carboxylic acid moiety, enabling direct coupling reactions. This reactivity profile supports efficient derivatization in synthetic organic chemistry, particularly for sulfonamide formation and conjugation workflows under standard conditions.
3-Chlorosulfonyl-4-methylbenzoic acid serves as a versatile building block for sulfonamide and sulfonyl chloride functionalization in medicinal chemistry. Its orthogonal reactivity enables selective derivatization of amine nucleophiles while maintaining compatibility with common protecting groups. The methyl and carboxylic acid functionalities support further functionalization, facilitating the synthesis of bioactive heterocycles and API intermediates. Bench-stable and readily purified by recrystallization, it functions reliably in standard coupling protocols.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H314
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501
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Lot numbers can be found on the outside label of a product: