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Structure of 372198-49-7
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5-Cyano-2-methyl-benzenesulfonyl chloride features a sulfonyl chloride group flanked by a cyano substituent and a methyl group on the aromatic ring. This electron-deficient architecture enables efficient coupling reactions in synthetic workflows, particularly for installing sulfonamide linkages under mild conditions. The ortho-methyl group provides steric stabilization, enhancing reactivity control and handling stability.
5-Cyano-2-methyl-benzenesulfonyl chloride serves as a versatile sulfonylating agent for the efficient installation of sulfonamide functionalities in medicinal chemistry and agrochemical synthesis. Its ortho-methyl and meta-cyano substituents enhance reactivity while maintaining bench stability, enabling clean transformations with amines under mild conditions. The molecule exhibits excellent functional group tolerance and facilitates straightforward purification, making it ideal for constructing complex heterocyclic scaffolds and sulfonamide-containing APIs.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H314
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501
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Lot numbers can be found on the outside label of a product: