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CS-W001157 4
Total: USD 88.00

5-Fluoro-2-iodoaniline

  • CAS No. 255724-71-1

  • Cat. No. CS-W002882
  • Purity≥98%
  • MDL No.MFCD02093953

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-2-iodoaniline|CS-W002882

Structure of 255724-71-1

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General Information

  • CAS No. 255724-71-1
  • Cat. No. CS-W002882
  • Purity ≥98%
  • MDL No. MFCD02093953
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅FIN
  • Molecular Weight 237.01
  • Synonym(s) 5-Fluoro-2-iodobenzenamine
  • SMILES FC1=CC(N)=C(I)C=C1

Description

5-Fluoro-2-iodoaniline features a fluorine atom at the 5-position and an iodine substituent at the 2-position of the aniline ring, creating a highly functionalized aryl scaffold. This electron-deficient platform enables efficient cross-coupling reactions, particularly in palladium-catalyzed transformations. The molecule exhibits excellent stability under standard conditions and serves as a key intermediate for synthesizing bioactive compounds and advanced materials.

Application

5-Fluoro-2-iodoaniline serves as a versatile building block for Suzuki-Miyaura and Ullmann-type coupling reactions, enabling efficient construction of biaryl scaffolds. Its ortho-iodo functionality exhibits high reactivity under standard palladium catalysis, while the meta-fluoro group offers orthogonal handle for further functionalization. The compound demonstrates excellent bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H412
Precautionary Statements : P264-P270-P273-P330-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.0125
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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