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CS-W001157 4
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Propylene glycol monolaurate,Isomeric mixtures

  • CAS No. 27194-74-7

  • Cat. No. CS-0641576
  • Purity95% (isomers mixture)
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Propylene glycol monolaurate,Isomeric mixtures|CS-0641576

Structure of 27194-74-7

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General Information

  • CAS No. 27194-74-7
  • Cat. No. CS-0641576
  • Purity 95% (isomers mixture)
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₃₀O₃
  • Molecular Weight 258.40
  • Synonym(s) None
  • SMILES CCCCCCCCCCCC(OC(CO)C)=O.CCCCCCCCCCCC(OCC(O)C)=O

Description

A cell-permeable styrylquinazoline compound that preferentially induces apoptotic death of mutant p53-harboring H1299-His175 and Saos-2-His273 tumor cells (IC50 = 3.4 and 4.9 M, respectively), while exhibiting much reduced potency towards p53-null (IC50 = 9.6, 11.4, and 14.7 M against H1299, Saos-2, and HCT116, respectively) or wild-type p53-expressing (IC50 = 13.2 and 20.3 M against HCT116 and HDF, respectively) cells. STIMA-1 is demonstrated to covalently modify free thiols on mutant p53 in H1299-His175 cells and fully restore its DNA binding activity to the level seen with wild-type p53, resulting in upregulation of p53-dependent gene expression, including p21, PUMA, and Bax.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   93.06
  • LogP   7.6626
  • H_Acceptors   6
  • H_Donors   2
  • Rotatable_Bonds   24

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