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CS-W001157 4
Total: USD 88.00

AC-CYS(TRT)-OH

  • CAS No. 27486-87-9

  • Cat. No. CS-0040956
  • Purity≥98%
  • MDL No.MFCD00236747

*For research and further manufacturing use only, not for direct human use.

AC-CYS(TRT)-OH|CS-0040956

Structure of 27486-87-9

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General Information

  • CAS No. 27486-87-9
  • Cat. No. CS-0040956
  • Purity ≥98%
  • MDL No. MFCD00236747
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₄H₂₃NO₃S
  • Molecular Weight 405.51
  • Synonym(s) NSC 124673
  • SMILES O=C(O)[C@H](CSC(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)NC(C)=O

Application

AC-CYS(TRT)-OH serves as a protected cysteine building block for peptide synthesis, offering stable thiol protection via the trifluoromethylthio (TRT) group. It facilitates efficient coupling reactions with minimal racemization and enables selective deprotection under mild conditions. The acetyl-protected amine ensures compatibility with standard Fmoc-SPPS protocols, while the TRT group provides orthogonal handling in complex sequence assembly. Ideal for incorporating cysteine residues into therapeutic peptides and macrocyclic scaffolds.

Synthesis

  • Route1
    • In-stock
      S-Trityl-L-cysteine|CS-W011818
      2799-07-7
    • null|null
      108-24-7
    • ~60%
    • In-stock
      AC-CYS(TRT)-OH|CS-0040956
      27486-87-9

    References

    • Zheng, Yan; Duanmu, Chuansong; Gao, Yong Organic Letters, 2006 , vol. 8, # 15 p. 3215 - 3217
  • Route2
    • In-stock
      Acetylcysteine extracted from plants|CS-0646650
      616-91-1
    • null|null
      76-83-5
    • ~79%
    • In-stock
      AC-CYS(TRT)-OH|CS-0040956
      27486-87-9

    References

    • Loukou, Christina; Changenet-Barret, Pascale; Rager, Marie-Noelle; Plaza, Pascal; Martin, Monique M.; Mallet, Jean-Maurice Organic and Biomolecular Chemistry, 2011 , vol. 9, # 7 p. 2209 - 2218
  • Route3
    • null|null
      76-83-5
    • ~%
    • In-stock
      AC-CYS(TRT)-OH|CS-0040956
      27486-87-9

    References

    • Zheng, Yan; Duanmu, Chuansong; Gao, Yong Organic Letters, 2006 , vol. 8, # 15 p. 3215 - 3217

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   66.4
  • LogP   4.301
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   8

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