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CS-W001157 4
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7-Bromo-3-iodo-1-methyl-1H-indazole

  • CAS No. 2757023-58-6

  • Cat. No. CS-0911611
  • Molecule weight336.96
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7-Bromo-3-iodo-1-methyl-1H-indazole|CS-0911611

Structure of 2757023-58-6

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General Information

  • CAS No. 2757023-58-6
  • Cat. No. CS-0911611
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆BrIN₂
  • Molecular Weight 336.96
  • Synonym(s) None
  • SMILES CN1N=C(I)C2=C1C(Br)=CC=C2

Description

7-Bromo-3-iodo-1-methyl-1H-indazole features a dual halogenated indazole core with orthogonal reactivity, enabling sequential cross-coupling transformations. The electron-deficient heterocycle integrates readily into complex scaffolds under palladium catalysis, while the methyl group enhances solubility and metabolic stability in synthetic intermediates.

Application

7-Bromo-3-iodo-1-methyl-1H-indazole serves as a versatile building block for transition-metal-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. The bromo and iodo substituents exhibit complementary reactivity in Pd-catalyzed coupling processes, while the methyl group enhances solubility and modulates electronic properties. Bench-stable and readily purified by flash chromatography, it facilitates streamlined synthesis of complex indazole-based architectures relevant to medicinal chemistry and materials science.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   17.82
  • LogP   2.9404
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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