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Structure of 27828-71-3
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5-Hydroxynicotinic acid is a bench-stable, electron-deficient heterocycle bearing a carboxylic acid and phenolic hydroxyl group at adjacent positions on the pyridine ring. This dual functionality enables direct coupling in peptide synthesis and facilitates metal chelation for catalytic applications. The molecule integrates readily into bioactive scaffolds requiring hydrogen-bonding motifs or redox-active centers.
5-Hydroxynicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of heterocyclic scaffolds and bioactive molecules through established coupling and cyclization protocols. Its ortho-hydroxy group facilitates chelation and enhances solubility, while the carboxylic acid functionality supports direct derivatization or activation for amide bond formation. Bench-stable and readily purified by recrystallization, it functions reliably in standard synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: