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Structure of 394-04-7
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5-Fluoro-2-methoxybenzoic acid features a fluorine atom at the meta position and a methoxy group at the ortho position relative to the carboxylic acid, creating a uniquely polarized aromatic scaffold. This combination enhances solubility in organic solvents while maintaining stability under standard bench conditions. The molecule integrates readily into synthetic routes requiring electron-deficient aryl building blocks, particularly in medicinal chemistry applications targeting kinase inhibitors and bioactive heterocycles.
5-Fluoro-2-methoxybenzoic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation into bioactive scaffolds via standard esterification, amide coupling, and Suzuki-Miyaura cross-coupling reactions. Its ortho-methoxy and meta-fluoro substituents provide enhanced electronic modulation and metabolic stability, while the carboxylic acid functionality ensures straightforward derivatization and purification. The compound exhibits excellent bench stability and functional group tolerance, facilitating efficient synthesis of targeted heterocycles and pharmaceutical intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352
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Lot numbers can be found on the outside label of a product: