Methyl 3,6-dichloropyridazine-4-carboxylate

Name: Methyl 3,6-dichloropyridazine-4-carboxylate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 286946-24-5
Cat. No. CS-W020500
Purity≥96%
MDL No.MFCD12546173

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Methyl 3,6-dichloropyridazine-4-carboxylate|CS-W020500

Structure of 286946-24-5

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 286946-24-5
Cat. No. CS-W020500
Purity ≥96%
MDL No. MFCD12546173
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄Cl₂N₂O₂
Molecular Weight 207.02
Synonym(s) Methyl 3,6-dichloropyridazine-4-carboxylate, Fandachem
SMILES COC(C1=CC(Cl)=NN=C1Cl)=O

Description

Methyl 3,6-dichloropyridazine-4-carboxylate features a pyridazine core bearing two chlorine substituents and a methyl ester group, enabling efficient functionalization in heterocyclic synthesis. This electron-deficient scaffold integrates readily into pharmaceutical intermediates and agrochemical building blocks under standard conditions.

Application

Methyl 3,6-dichloropyridazine-4-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to substituted pyridazines via nucleophilic displacement. The dichloro substitution pattern provides orthogonal reactivity for sequential functionalization, while the ester group facilitates downstream transformations including hydrolysis, reduction, or coupling reactions. Its bench-stable nature and compatibility with standard reaction conditions make it well-suited for medicinal chemistry campaigns and process development.

Synthesis

Route1
- 67-56-1
- In-stock
  
  51149-08-7
- ~84%
- In-stock
  
  286946-24-5
References
- Roche Palo Alto LLC Patent: US2008/293664 A1, 2008 ; Location in patent: Page/Page column 18 ;
Route2
- In-stock
  
  51149-08-7
- 18107-18-1
- ~87%
- In-stock
  
  286946-24-5
References
- Sweeney, Zachary K.; Harris, Seth F.; Arora, Nidhi; Javanbakht, Hassan; Li, Yu; Fretland, Jennifer; Davidson, James P.; Billedeau, J. Roland; Gleason, Shelley K.; Hirschfeld, Donald; Kennedy-Smith, Joshua J.; Mirzadegan, Taraneh; Roetz, Ralf; Smith, Mark; Sperry, Sarah; Suh, Judy M.; Wu, Jeffrey; Tsing, Stan; Villasenor, Armando G.; Paul, Amber; Su, Guoping; Heilek, Gabrielle; Hang, Julie Q.; Zhou, Amy S.; Jernelius, Jesper A.; Zang, Fang-Jie; Klumpp, Klaus Journal of Medicinal Chemistry, 2008 , vol. 51, # 23 p. 7449 - 7458

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 52.08
LogP 1.57
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic heterocycle compounds Pyridazine compounds

Key Words

286946-24-5 sigma286946-24-5 manufacturer286946-24-5 price286946-24-5 structure286946-24-5 SDSbuy 286946-24-5286946-24-5 supplier286946-24-5 uses286946-24-5 molecular weightprice of 286946-24-5286946-24-5 chemical name formula of 286946-24-5

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

Methyl 3,6-dichloropyridazine-4-carboxylate

CAS No. 286946-24-5

Recommended Products